Expression of the Low-density Lipoprotein Receptor (LDLR) Gene Family in CD133+/CD44+ Prostate Cancer Stem Cells

Aim: The low-density lipoprotein receptor gene (LDLR) family plays a fundamental role in many malignancies and may have putative cancer-boosting function. In our study, we attempted to comparatively investigate the differential expressions of LDLR normal prostate epithelial cell line (RWPE-1), cancer (DU145 line), stem cells CSCs) non-CSCs non-CSCs, bulk population). 
 Materials Methods: Cancer DU-145 were isolated by flow cytometry according CD133 CD44 surface properties. Whole transcriptome sequencing data was comprehensively analyzed for each group. protein-protein interaction network determined using STRING protein database.
 Results: Our showed that expression levels LRP1, LRP3, LRP8 LRP11 increased DU145 CSCs relative line. Conclusion: Overall, suggest LRP functions and/or ultimately change invasive phenotype CSCs.